The idea that will change the game of knowledge is the realization that it is more important to understand events, objects, and processes in their relationship with each other than in their singular structure.
Western science has achieved wonders with its analytic focus, but it is now time to take synthesis seriously. We shall realize that science cannot be value-free after all. The Doomsday clock ticking on the cover of the Bulletin of Atomic Scientists ever closer to midnight is just one reminder that knowledge ignorant of consequences is foolishness.
Chemistry that shrugs at pollution is foolishness, Economics that discounts politics and sociology is just as ignorant as are politics and sociology that discount economics.
Unfortunately, it does not seem to be enough to protect the neutral objectivity of each separate science, in the hope that the knowledge generated by each will be integrated later at some higher level and used wisely. The synthetic principle will have to become a part of the fundamental axioms of each science. How shall this breakthrough occur? Current systems theories are necessary but not sufficient, as they tend not to take values into account. Perhaps after this realization sets in, we shall have to re-write science from the ground up.